Results
| PMID | 19050323 |
| Gene Name | CCL2 |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | CCR1,MCP-1, CA125 |
| Other associated phenotypes |
Endometriosis |
|
Reprod Sci. 2008 Nov;15(9):906-11. doi: 10.1177/1933719108318598. Agic, Admir| Djalali, Schima| Wolfler, Monika M| Halis, Gulden| Diedrich, Klaus| Hornung, Daniela Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Luebeck, Germany. This study investigated the possible use of CCR1 mRNA measurement in peripheral blood leukocytes in combination with measurements of monocyte chemotactic protein-1 (MCP-1) and CA125 protein in serum as a diagnostic test for endometriosis.The expression of CCR1 mRNA in peripheral blood leukocytes was measured by quantitative real-time polymerase chain reaction. MCP-1 and CA125 levels in serum were determined by ELISA and ECLIA.The ratio of CCR1/HPRT mRNA in peripheral blood of patients with endometriosis and adenomyosis was significantly elevated compared with women without endometriosis. Additionally, serum levels of MCP-1 and CA125 were significantly higher in patients with endometriosis. This method showed a sensitivity of 92.2%, a specificity of 81.6%, a negative predictive value of 83.3%, a positive predictive value of 92.3%, a likelihood ratio of a positive test result of 5.017, and a likelihood ratio of a negative test result of 0.096 to predict the presence or absence of endometriosis.The results imply the potential use of CCR1 mRNA, MCP-1, and CA125 protein measurements for the diagnosis or exclusion of endometriosis. Mesh Terms: CA-125 Antigen/*blood| Chemokine CCL2/*blood| Endometriosis/*blood/diagnosis| Female| Humans| RNA, Messenger/blood| Receptors, CCR1/*blood/genetics| Retrospective Studies|DA 2009/02/03 09:00 |
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